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Sunday, May 29, 2011

Insecticides Modes of Action-Part 1

Today I will continue to write about Insecticides Mode of Actions. If you have forgotten how does nervous system work, you may read my previous post on First Step to Understand Insecticides Mode of Actions .

Extract from my previous blogpost.

"Incoming signals (Touching on hot kettle) are transformed by the neuron into an electrical charge and these charge particals are called ions. These ions will move through channels at the neurons. There are 4 MAIN CHANNELS which allow DIFFERENT IONS to be moved along the neurons. "

1) Calcium Channels
2) Chloride Channels
3) Potassium Channels
4) Sodium Channels
Many channels will have its own gates for opening and closing. This is important and that's how the insecticides work in disrupting the nervous system. Please look at the below photos. This is exactly what I mean that, the channels have its own gate.





It shows clearly, only pentagon shape can go through the gate. Before, I continue with the biological explanation on mode of actions, I will make things simplify by giving you some illustrations.

(Photo 1)
The above blocks illustrate channels of the end of  Neuron A.


(Photo 2)
And this row of blocks illustrates receptors of the receiving end of Neuron B

Back to the below picture...



please bear in mind that from 'Touching the Hot Kettle' from your finger to send the impulse to your brain, it involves a lot of neurons and therefore, you have illustration of Photo 1 (Neuron A) and Photo 2 (Neuron B).

And Photo 3...



(Photo 3)
This piece of paper represent activity which happens in between Neuron A and Neuron B.



Photo 4 shows the nervous system is normal without any disruption from the chemicals

Let's take an example that the below Photo 5, represents Chemical A and Photo 6, represents Chemical B.



Photo 5
(Chemical A)

Photo 6
(Chemical B)

The fact is, these 2 tools are different because 1 scissor and 1 knife. However, both of their mode of actions... (Let's take for an example..) the 2 tools have been set a command to cut anything into half, and therefore from Photo 3, it will become Photo 7.



Photo 7
This has disrupted the normal nervous system and the illustration is as shown in Photo 8.

Photo 8
In a nutshell, if Chemical A and Chemical B are having the same mode of actions (Please notice that I used both tools in BLACK to represent same mode of actions) and you are rotating these 2 chemicals for your insects control, you are actually not doing the right job. You thought that you are rotating the chemicals for the purpose to prevent insects resistance but actually you are not. You are just rotating the brand of chemicals. Brand is just a brand and does not tell you group of chemicals. You need to look at the label giving you information on Active Ingredients (A.I.). From there, you must be knowledgeable on group of chemicals and understanding on group of chemicals will only tell you what type of chemicals shall you rotate with. It does not just end at the A.I. info only.
Another example,

Photo 9
(Chemical C)

Compare Photo 5 (Chemical A) and Photo 9 (Chemical C). Both are scissors but this time I will set Photo 9 mode of action to cut anything into triangle. From Photo 3, a piece of rectangular paper will become triangle, Photo 10.



Photo 10

Again...this has disrupted the normal nervous system and the illustration is shown as below.


Photo 11

The above illustrations tell us, if you rotate Photo 5 (Chemical A) with Photo 6 (Chemical B), you are actually not rotating because the mode of actions of these both chemicals are the same. In fact, if you rotate Photo 5 (Chemical A) with Photo 9 (Chemical C), you are doing a good job in chemical rotation. This is because their mode of actions are totally different.

Phew! This is a long topic. I wish I can continue to write on the biological explanation but I guess it's a bit too long for this time. I will reserve it for next week. If you understand the above illustrations, it will make you easier to understand on the next blogpost. Some people may find it confusing on the biological explanation.








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